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3

抑制剂 & 化合物

3

天然产物

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Cat. No. Product Name Target Signaling Pathways
T35801 ML-262

ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).
T74716 Curcumin 5-8

Curcumin 5-8 (CUR5-8),一种CUR类天然活性姜黄素类似物,具有抑制脂滴形成、促进细胞自噬 (autophagy)、抑制细胞凋亡 (Apoptosis) 以及改善胰岛素抵抗和胰岛素敏感性的功能。
T35445 1-Stearoyl-3-Oleoyl-rac-glycerol

1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-oleoyl-rac-glycerol in New Zealand obese (NZO) mice.1 The concentration of 1-stearoyl-3-oleoyl-rac-glycerol decreases from 4.59 to 1.88% during the dry-curing process of Iberian ham.2References1. Baumeier, C., Kaiser, D., Heeren, J., et al. Caloric restriction and intermittent fa...

化合物

ML-262
Cat.No: T35801
Synonym:
Target:
Curcumin 5-8
Cat.No: T74716
Synonym:
Target:
1-Stearoyl-3-Oleoyl-rac-glycerol
Cat.No: T35445
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S1173 Agrimol B

仙鹤草酚B,仙鹤草酚 B

Sirtuin; PPAR Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。
T36226 Beauveriolide I

Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i...
T36227 Beauveriolide III

Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...

天然产物

Agrimol B
Cat.No: T4S1173
Synonym: 仙鹤草酚B,仙鹤草酚 B
Target: Sirtuin, PPAR
Beauveriolide I
Cat.No: T36226
Synonym:
Target:
Beauveriolide III
Cat.No: T36227
Synonym:
Target:
TargetMol Loading
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